Started just over a year ago, Marian Regional Medical Center's Neuroboxing class is designed to help Parkinson's patients develop agility, muscular endurance, balance, hand-eye coordination, footwork and overall strength. Parkinson's disease — a nervous system disorder which is estimated to afflict around 1 million Americans — causes slowness, rigidity, loss of balance, tremors and other symptoms, said neurologist Dr. David Hardesty. In a third-floor office suite at the Marian Hancock Medical Building Monday, personal trainer April Sargeant yelled words of encouragement to a group of 14 people with Parkinson's disease. Standing in front boxing bags, each person punched the bag over and over, shifting their weight from leg to leg as they switched arms.